Why choose ALPE?

Modelling hypoxemia

The traditional ways to treat hypoxemic patients are supplementary oxygen, diuretics or by alveoli recruitment techniques such as for example CPAP. Our aim is to supply health care professionals with evidence to decide the most adequate treatment for the oxygenation problem.

ALPE essential is based on a mathematical model, which from breath-by-breath analysis and measurements of expired end-tidal oxygen (FetO2) and arterial saturation (SpO2) provides health care professionals with two parameters giving reliable pulmonary gas exchange insight. The measurements are non-invasive and can be done bedside in app. 5-8 minutes. The staff utilization of the system is user-friendly by a simple and self-explaining interface.
 

ALPE essential ascribes hypoxemia to ventilation-perfusion mismatch and pulmonary shunt. Gas exchange impairment is thereby divided into a part that can be treated with oxygen therapy and a part which will not respond to extra oxygen, respectively.

The method consists of solving a mathematical gas exchange model by making the best fit to the measured end-tidal expiratory oxygen (FetO2) and arterial saturation (SpO2) levels. As a result two clinical parameters are presented: Ventilation-perfusion mismatch as quantified by the first parameter, O2 - loss which is the extra oxygen that the patient require.
 

The second parameter is the pulmonary shunt. Completely blocked alveoli result in perfused but not ventilated areas of the lung. In these areas no gas exchange can happen. It has e.g. been shown that the area of the atelectatic lung region correlates significantly with increased shunt.

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